Bone Induction by BMPs/OPs and Related Family Members in Primates: The Critical Role of Delivery Systems

@article{Ripamonti2001BoneIB,
  title={Bone Induction by BMPs/OPs and Related Family Members in Primates: The Critical Role of Delivery Systems},
  author={Ugo Ripamonti and Lentsha Nathaniel Ramoshebi and Thato Matsaba and J Tasker and Jean Crooks and June Teare},
  journal={The Journal of Bone \& Joint Surgery},
  year={2001},
  volume={83},
  pages={S116–S127}
}
Background: In a series of studies in the primate Papio ursinus, we have examined the capacity of bone morphogenetic proteins (BMPs/OPs) delivered in a variety of biomaterial carrier systems to elicit bone formation in heterotopic and orthotopic sites. In this review, we compare the osteoinductive effects of different biomaterial delivery systems that have or have not been pretreated with BMPs/OPs. In particular, we focus on the geometric induction of bone formation by sintered porous… Expand
Bone morphogenetic proteins in craniofacial and periodontal tissue engineering: experimental studies in the non-human primate Papio ursinus.
The bone morphogenetic and osteogenic proteins (BMPs/OPs), pleiotropic members of the transforming growth factor-beta (TGF-beta) supergene family act as soluble signals for the de novo initiation ofExpand
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TLDR
Rec recombinant adenoviruses expressing the 14 types of BMPs are used and it is demonstrated that BMP-6 and B MP-9 effectively induced orthotopic ossification when either AdBMP-transduced osteoblast progenitors or the viral vectors were injected into the quadriceps of athymic mice. Expand
Recapitulating development: a template for periodontal tissue engineering.
TLDR
The induction of the complex tissue morphologies of the periodontal tissues in the nonhuman primate Papio ursinus with furcation defects treated with doses of naturally derived and recombinantly produced human BMPs/OPs is reviewed. Expand
Transforming growth factor-beta isoforms and the induction of bone formation: implications for reconstructive craniofacial surgery.
TLDR
The induction of bone formation by the osteogenic proteins of the TGF-beta superfamily in the nonhuman primate P. ursinus is highlighted and combinatorial applications of myoblastic/myogenic stem cell-based therapeutics for bone induction and morphogenesis are reviewed. Expand
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The results suggest an osteogenic hierarchical model in which BMP-2, 6, and 9 may play an important role in inducing osteoblast differentiation of mesenchymal stem cells, whereas most BMPs are able to stimulate osteogenesis in mature osteoblasts. Expand
Tissue engineered bone using select growth factors: A comprehensive review of animal studies and clinical translation studies in man.
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Focus is drawn to the in vivo success of osteoinductive growth factors incorporated within material implants both in animals and humans, and identifies the unmet challenges within the skeletal regenerative area. Expand
Tissue segregation restores the induction of bone formation by the mammalian transforming growth factor-β(3) in calvarial defects of the non-human primate Papio ursinus.
A diffusion molecular hypothesis from the dura and/or the leptomeninges below that would control the induction of calvarial membranous bone formation by the recombinant human transforming growthExpand
Soluble, insoluble and geometric signals sculpt the architecture of mineralized tissues
  • U. Ripamonti
  • Chemistry, Medicine
  • Journal of cellular and molecular medicine
  • 2004
TLDR
In the primate Papio ursinus, the induction of bone formation has been extended to the TGF‐β isoforms per se and of particular interest is that biomimetic matrices with intrinsic osteoinductivity would be an affordable option in the local context. Expand
Tissue engineering: TGF-beta superfamily members and delivery systems in bone regeneration.
TLDR
The basis of bone tissue engineering by members of the TGF-beta superfamily is outlined, focusing on their delivery systems and the intrinsic induction of bone formation by specific biomimetic matrices with a defined geometry. Expand
Bone induction by recombinant human osteogenic protein‐1 (hOP‐1, BMP‐7) in the primate Papio ursinus with expression of mRNA of gene products of the TGF‐β superfamily
  • U. Ripamonti
  • Biology, Medicine
  • Journal of cellular and molecular medicine
  • 2005
TLDR
The induction of bone by hOP‐1 in Papio ursinus develops as a mosaic structure with distinct spatial and temporal patterns of gene expression of members of the TGF‐β superfamily that singly, synergistically and synchronously initiate and maintain tissue induction and morphogenesis. Expand
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