Bone Effects of Biologic Drugs in Rheumatoid Arthritis

  title={Bone Effects of Biologic Drugs in Rheumatoid Arthritis},
  author={Addolorata Corrado and Anna Neve and Nicola Maruotti and Francesco Paolo Cantatore},
  booktitle={Clinical & developmental immunology},
Biologic agents used in the treatment of rheumatoid arthritis (RA) are able to reduce both disease activity and radiographic progression of joint disease. These drugs are directed against several proinflammatory cytokines (TNF α , IL-6, and IL-1) which are involved both in the pathogenesis of chronic inflammation and progression of joint structural damage and in systemic and local bone loss typically observed in RA. However, the role of biologic drugs in preventing bone loss in clinical… CONTINUE READING
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