Bone Density in Ehlers-Danlos Syndrome

  title={Bone Density in Ehlers-Danlos Syndrome
  author={Laura D. Carbone and Francis Tylavsky and Andrew J. Bush and Winston W. K. Koo and Eric S. Orwoll and Sulin Cheng},
  journal={Osteoporosis International},
Abstract: Ehlers-Danlos Syndrome (EDS) is the most common inherited disorder of connective tissue recognized. The objectives of the present study were to determine bone mineral density (BMD) and biochemical markers of bone metabolism in EDS. Twenty-three subjects with Type III EDS and 23 matched controls underwent BMD measurement by dual-Energy X-ray absorptiometry (DXA) of the lumbar spine and femoral neck. Health history questionnaires and biochemical markers of bone and connective tissue… 

Bone involvement in adult patients affected with Ehlers-Danlos syndrome.

A reduced BMD and bone quality and increased prevalence of asymptomatic vertebral fractures in eugonadal patients with Ehlers-Danlos syndrome is found and the need of a bone health evaluation in these patients is suggested.

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The occurrence of marked osteoporosis in the peripheral skeleton of EDS patients as an additional, yet heretofore unrecognized, manifestation of bone mineral density in the scoliotic lumbar spine is reported.

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A structured approach to clinical management of bone metabolic complication in EDS is proposed and indicates that mechanism of bone damage are probably multifactorial in line with the different skeletal phenotypes.



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It is reported that measurement of the urinary excretion of pyridinium cross-links serves as a simple, noninvasive diagnostic test for Ehlers-Danlos syndrome type VI.

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