Bone Density in Ehlers-Danlos Syndrome

  title={Bone Density in Ehlers-Danlos Syndrome
  author={Laura D. Carbone and Francis Tylavsky and Andrew J. Bush and Winston W. K. Koo and Eric S. Orwoll and Sulin Cheng},
  journal={Osteoporosis International},
Abstract: Ehlers-Danlos Syndrome (EDS) is the most common inherited disorder of connective tissue recognized. The objectives of the present study were to determine bone mineral density (BMD) and biochemical markers of bone metabolism in EDS. Twenty-three subjects with Type III EDS and 23 matched controls underwent BMD measurement by dual-Energy X-ray absorptiometry (DXA) of the lumbar spine and femoral neck. Health history questionnaires and biochemical markers of bone and connective tissue… 

Bone involvement in adult patients affected with Ehlers-Danlos syndrome.

A reduced BMD and bone quality and increased prevalence of asymptomatic vertebral fractures in eugonadal patients with Ehlers-Danlos syndrome is found and the need of a bone health evaluation in these patients is suggested.

Low bone mass in Ehlers-Danlos syndrome.

The occurrence of marked osteoporosis in the peripheral skeleton of EDS patients as an additional, yet heretofore unrecognized, manifestation of bone mineral density in the scoliotic lumbar spine is reported.

Bone Disease in Patients with Ehlers–Danlos Syndromes

It might be justified to perform spine radiographs and bone mineral density assessments in newly diagnosed EDS, and vertebral abnormalities seem to be common in classical and hypermobile EDS.

Higher fracture prevalence and smaller bone size in patients with hEDS/HSD—a prospective cohort study

It is found that hEDS/HSD patients present with a cortical bone size deficit compared with control subjects, possibly related to lower mechanical loading, which is likely secondary to decreased mechanical loading.

The first experience of denosumab therapy on patients with Ehlers–Danlos syndrome and osteoporosis: detailed observation of two patients

Denosumab exerted a fluctuating but probably positive effect regarding BMD and could be a treatment option on these patients with EDS and osteoporosis.



Molecular Basis of Clinical Heterogeneity in the Ehlers‐Danlos Syndrome a

Mutations which give rise to the many different phenotypes of the Ehlers-Danlos syndrome affect both collagen and noncollagen genes but, ultimately, affect the function of the major collagens in

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A survey of 151 EDS patients showed a high percentage of the patients were classified as having Types I through IV, and Bracing and fusion appear to be the most commonly used methods of orthopedic care.

Urinary pyridinium cross-links: a noninvasive diagnostic test for Ehlers-Danlos syndrome type VI.

It is reported that measurement of the urinary excretion of pyridinium cross-links serves as a simple, noninvasive diagnostic test for Ehlers-Danlos syndrome type VI.

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Contrary to earlier published observations, the Ehlers Danlos syndrome may be relatively more benign, from the cardiac point of view, than was previously thought.

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The orthopaedic features of 100 patients with the Ehlers-Danlos syndrome are described and comment is made of their relationship to the other stigmata of the syndrome.

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