Bone Density in Ehlers-Danlos Syndrome

@article{Carbone2000BoneDI,
  title={Bone Density in Ehlers-Danlos Syndrome
},
  author={Laura D. Carbone and Francis Tylavsky and Andrew J. Bush and Winston W. K. Koo and Eric S. Orwoll and Sulin Cheng},
  journal={Osteoporosis International},
  year={2000},
  volume={11},
  pages={388-392}
}
Abstract: Ehlers-Danlos Syndrome (EDS) is the most common inherited disorder of connective tissue recognized. The objectives of the present study were to determine bone mineral density (BMD) and biochemical markers of bone metabolism in EDS. Twenty-three subjects with Type III EDS and 23 matched controls underwent BMD measurement by dual-Energy X-ray absorptiometry (DXA) of the lumbar spine and femoral neck. Health history questionnaires and biochemical markers of bone and connective tissue… 

Bone involvement in adult patients affected with Ehlers-Danlos syndrome.

A reduced BMD and bone quality and increased prevalence of asymptomatic vertebral fractures in eugonadal patients with Ehlers-Danlos syndrome is found and the need of a bone health evaluation in these patients is suggested.

Low bone mass in Ehlers-Danlos syndrome.

The occurrence of marked osteoporosis in the peripheral skeleton of EDS patients as an additional, yet heretofore unrecognized, manifestation of bone mineral density in the scoliotic lumbar spine is reported.

Bone Disease in Patients with Ehlers–Danlos Syndromes

It might be justified to perform spine radiographs and bone mineral density assessments in newly diagnosed EDS, and vertebral abnormalities seem to be common in classical and hypermobile EDS.

Higher fracture prevalence and smaller bone size in patients with hEDS/HSD—a prospective cohort study

It is found that hEDS/HSD patients present with a cortical bone size deficit compared with control subjects, possibly related to lower mechanical loading, which is likely secondary to decreased mechanical loading.

The first experience of denosumab therapy on patients with Ehlers–Danlos syndrome and osteoporosis: detailed observation of two patients

Denosumab exerted a fluctuating but probably positive effect regarding BMD and could be a treatment option on these patients with EDS and osteoporosis.

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