Bone Cancer Pain
@article{Clohisy2003BoneCP, title={Bone Cancer Pain}, author={D. Clohisy and P. Mantyh}, journal={Clinical Orthopaedics and Related Research}, year={2003}, volume={1}, pages={S279-S288} }
BACKGROUNDBone cancer pain is very common, and patients with this type of pain may be difficult to treat. Development of an experimental model for studying this condition is critical to advancing an understanding of the mechanisms that cause pain in patients with malignant disease. METHODSA murine model of bone cancer was studied. Combined analysis of the extent of tumor-induced bone destruction, pain, and neurochemical characterization of the peripheral and central nervous systems was… Expand
Topics from this paper
12 Citations
Single-agent pamidronate for palliative therapy of canine appendicular osteosarcoma bone pain
- Medicine
- 2007
- 20
Involvement of the spinal NMDA receptor/PKCγ signaling pathway in the development of bone cancer pain
- Medicine
- Brain Research
- 2010
- 24
Use of force plate analysis to evaluate the efficacy of external beam radiation to alleviate osteosarcoma pain.
- Medicine
- Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
- 2009
- 17
The cortical representation of sensory inputs arising from bone
- Biology, Medicine
- Brain Research
- 2009
- 10
References
SHOWING 1-10 OF 59 REFERENCES
Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord
- Medicine
- Nature Medicine
- 2000
- 454
Neurochemical and Cellular Reorganization of the Spinal Cord in a Murine Model of Bone Cancer Pain
- Medicine
- The Journal of Neuroscience
- 1999
- 477
- PDF
Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur
- Medicine
- Neuroscience
- 2002
- 497
Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons
- Medicine
- Neuroscience
- 2000
- 516
Differential patterns of bone turnover in relation to bone pain and disease extent in bone in cancer patients with skeletal metastases.
- Chemistry, Medicine
- Clinical chemistry
- 1999
- 111
- PDF
Localized, tumor‐associated osteolysis involves the recruitment and activation of osteoclasts
- Chemistry, Medicine
- Journal of orthopaedic research : official publication of the Orthopaedic Research Society
- 1996
- 73
Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis.
- Medicine
- The Journal of clinical investigation
- 1996
- 782
- PDF