Bone Cancer Pain

  title={Bone Cancer Pain},
  author={D. Clohisy and P. Mantyh},
  journal={Clinical Orthopaedics and Related Research},
  • D. Clohisy, P. Mantyh
  • Published 2003
  • Medicine
  • Clinical Orthopaedics and Related Research
  • BACKGROUNDBone cancer pain is very common, and patients with this type of pain may be difficult to treat. Development of an experimental model for studying this condition is critical to advancing an understanding of the mechanisms that cause pain in patients with malignant disease. METHODSA murine model of bone cancer was studied. Combined analysis of the extent of tumor-induced bone destruction, pain, and neurochemical characterization of the peripheral and central nervous systems was… CONTINUE READING
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