Bone: IGFBP1—hepatokine and target for FGF21-mediated bone loss

  title={Bone: IGFBP1—hepatokine and target for FGF21-mediated bone loss},
  author={Robert F. Phillips},
  journal={Nature Reviews Endocrinology},
Insulin-like growth factor-binding protein 1 (IGFBP1) has been identified as a hormone that is produced in the liver and promotes osteoclastogenesis and bone resorption, in a new study published in Cell Metabolism. IGFBP1 blockade is now a target for the treatment of conditions such as osteoporosis, and could enable inhibition of bone loss mediated by fibroblast growth factor 21 (FGF21; a potential therapeutic agent for diabetes mellitus), without inhibiting insulin sensitivity. Wang and co… CONTINUE READING
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