Bone: Formation by Autoinduction

  title={Bone: Formation by Autoinduction},
  author={M. Urist},
  pages={893 - 899}
Wandering histiocytes, foreign body giant cells, and inflammatory connective-tissue cells are stimulated by degradation products of dead matrix to grow in and repopulate the area of an implant of decalcified bone. Histiocytes are more numerous than any other cell form and may transfer collagenolytic activity to the substrate to cause dissolution of the matrix. The process is followed immediately by new-bone formation by autoinduction in which both the inductor cells and the induced cells are… Expand
Chondroclasts in osteoneogenesis.
DBP was implanted into rat rectus abdominis muscle to induce osteoneogenesis and large polynucleated cells appear in the implant after calcification of the cartilage matrix, leading to the conclusion that they are chondroclasts. Expand
Induction of osteogenesis by demineralized homologous and xenograft bone matrix
The segmental resection is routine for primary andmetastics tumors of the mandible. The reconstructiveoptions are very limited due to the large amount ofsoft tissues resected which may lead toExpand
The induction of reparative dentine in the amputated dental pulp of the dog by bone morphogenetic protein.
It is suggested that dissolved BMP stimulates mitosis of mesenchymal cells and may induce differentiation of osteodentinocytes and the resultant osteodentine may play some role in the differentiation of odontoblasts. Expand
Bone-Inducing Factors in Osteoinductive Implants
Over the last decade, considerable attention has been focused on the cellular and molecular aspects of bone cell biology. In spite of advances in this area and in biomaterials science, autogeneicExpand
Cellular response to osteoinductive materials in orthopaedic surgery
The chapter presents current work utilising various porous cell seeded scaffolds, bioactive factors, recombinant signalling molecules, and stem cells, and their capacity for osseous regeneration and the role of these materials in the future management of skeletal disorders and state-of-the-art trauma and reconstructive surgery. Expand
Effects of bone matrix components on osteoclast differentiation.
These studies support the hypothesis that osteocalcin may function as a matrix signal in the differentiation of osteoclasts and support the idea that osteoclast features include resorption of the bone substrate, ruffled borders, calcitonin receptors, tartrate-resistant acid phosphatase activity, and modulation by bone active agents. Expand
Delivery Systems for Osteoinductive Proteins
Bone morphogenetic proteins (BMPs) have been investigated for three decades. The fact that demineralized bone and extracts of demineralized bone are osteoinductive was first shown by Urist [1]. TheExpand
The healing potential of the periosteum molecular aspects.
An essential knowledge of the basics related to the contribution of the periosteum in the healing of fractures, osteotomies, during the process of distraction osteogenesis and in some degree in the repair of cartilagenous defects provides the surgeons with a better insight to understand the upcoming "biological" interventions in the management of skeletal injuries. Expand
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Induced chondroblastic differentiation of human fibroblasts by three-dimensional culture with demineralized bone matrix
Demineralized bone powder (DBP) implanted in vivo induces endochondral bone formation (osteoinduction). Connective tissue cells migrate to the powders and they begin to produce cartilage matrix.Expand


Induction of cell differentiation. I. The in vitro induction of vertebral cartilage with a low-molecular-weight tissue component.
This fraction induces the formation of cartilage in explanted somites and the ability to induce cartilage formation has been restricted to one nucleotide-containing component. Expand
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Immunization of host mice to homograft tissues prior to subcutaneous implantation of homograft bone' within diffusion chambers did not prevent new bone formation on the host side of the filter,Expand
It still remains to be determined which of the various types of devitalized bone may serve best in facilitating healing of a skeletal defect. Expand
An experimental analysis of the development of the spinal column. VI. Aspects of cartilage induction.
Abstract Both the embryonic spinal cord and notochord induce the formation of cartilage in a population of chick somite cells. This inducing capacity is relatively specific—most other living andExpand
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