The purpose of this clinical trial was to evaluate, over a 12-month period, the clinical bond failure of adhesive precoated brackets (APC) or conventional brackets using self-etching primers (SEP) or conventional bonding technique in a sample of North-Eastern Thai orthodontic patients. Sixty randomly selected patients who required full fixed appliances were recruited in a single center randomized clinical trial using a split mouth design was used. A total of 1,030 brackets were bonded. There were no significant difference in bond failure between both conventionally bonded brackets and APC brackets (P=0.29) and conventional bonding with SEP (P=0.52). Cox’s proportional hazard regression showed that SEP had 1.31 times more chance of bracket failure than conventional bonding and the APC brackets had 1.56 times to prevent bond failure than conventional brackets. No statistically significant differences were found for survival rate with respect to bracket system, bonding technique. Thus, APC and SEP appear to offer viable alternative for orthodontic bonding materials.