Bombesin stimulates the motility of human prostate‐carcinoma cells through tyrosine phosphorylation of focal adhesion kinase and of integrin‐associated proteins

@article{Aprikian1997BombesinST,
  title={Bombesin stimulates the motility of human prostate‐carcinoma cells through tyrosine phosphorylation of focal adhesion kinase and of integrin‐associated proteins},
  author={A. Aprikian and L. Tremblay and K. Han and S. Chevalier},
  journal={International Journal of Cancer},
  year={1997},
  volume={72}
}
Bombesin‐like peptides, including the mammalian homologue gastrin‐releasing peptides, are highly expressed and secreted by neuroendocrine cells in prostate carcinoma (PCa) tissues and are likely to be related to the progression of this disease. In the present study, we show that bombesin enhances the migration of androgen‐independent PCa cells (PC‐3) in vitro, while not affecting their adhesion to extracellular matrix proteins. The bombesin‐increased motility of PC‐3 cells occurs through its… Expand
Focal adhesion kinase is required for bombesin-induced prostate cancer cell motility
Bombesin modulates the association of Src with a nuclear 110-kd protein expressed in dividing prostate cells.
Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signaling.
Bombesin stimulates adhesion, spreading, lamellipodia formation, and proliferation in the human colon carcinoma Isreco1 cell line.
Bombesin stimulates nuclear factor kappa B activation and expression of proangiogenic factors in prostate cancer cells.
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