Bombesin stimulates proliferation of human breast cancer cells in culture.

  title={Bombesin stimulates proliferation of human breast cancer cells in culture.},
  author={John Nelson and Michael Donnelly and Brian Walker and Joe Gray and Chad Shaw and Richard F. Murphy},
  journal={British Journal of Cancer},
  pages={933 - 936}
The discovery of the amphibian skin tetradecapeptide bombesin led to the identification of several mammalian bombesin-like neuroendocrine peptides such as gastrinreleasing peptides (GRP'-27 and GRP"8-27) and neuromedin B. GRP and neuromedin B are products of two distinct genes (Krane et al., 1988). Bombesin and its homologues stimulate gastric acid secretion and cause release of various peptide hormones (Dockray, 1987). Bombesin is also mitogenic, causing gastrin cell hyperplasia in rats… CONTINUE READING
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