Corpus ID: 10611190

Bombesin-induced pancreatic secretion and growth in rats: effect of proglumide, spantide and ranitidine.

  title={Bombesin-induced pancreatic secretion and growth in rats: effect of proglumide, spantide and ranitidine.},
  author={C. Scarpignato and G. Varga and I. Dobronyi and M. Papp},
  journal={International journal of tissue reactions},
  volume={12 5},
The effect of proglumide (400 mg/kg), spantide (400 g/kg) and ranitidine (20 mg/kg) on pancreatic secretory and trophic response to bombesin (10 micrograms/kg) was studied in the rat. Drugs were administered alone or combined with bombesin three times daily for 5 days. Saline-treated rats were used as controls. At the end of treatment, animals were anaesthetized and pancreatic juice was collected for 1 h after caerulein stimulation (1 microgram/kg intraperitoneally). Afterwards, rats were… Expand
3 Citations
Effect of lithium on secretory factors and growth stimulation by bombesin in rat pancreas and salivary glands.
The stimulatory effect of bombsin on the growth and protein content of the pancreas and the salivary gland was inhibited by lithium, which seems to be a potent inhibitor of growth factors induced by bombesin probably through inhibiting phosphatidylinositol 4,5,bisphosphate hydrolysis. Expand
Gastrin-releasing peptide messenger ribonucleic acid expression in the hypothalamic paraventricular nucleus is altered by melanocortin receptor stimulation and food deprivation.
It is demonstrated that food deprivation and stimulation of the melanocortin system produce opposing changes in GRP gene expression in the PVN, suggesting that GRP-containing neurons inThe PVN may be part of the hypothalamic signaling pathway controlling food intake and energy balance. Expand
Endoscopical and pathological dissociation in severe colitis induced by immune-checkpoint inhibitors
It is proposed that performing random colonic biopsies should be considered in cases of immune checkpoint-associated unexplained diarrhea, even when colonoscopy shows macroscopically normal colonic mucosa inflammatory lesions. Expand