Corpus ID: 10611190

Bombesin-induced pancreatic secretion and growth in rats: effect of proglumide, spantide and ranitidine.

@article{Scarpignato1990BombesininducedPS,
  title={Bombesin-induced pancreatic secretion and growth in rats: effect of proglumide, spantide and ranitidine.},
  author={C. Scarpignato and G. Varga and I. Dobronyi and M. Papp},
  journal={International journal of tissue reactions},
  year={1990},
  volume={12 5},
  pages={
          299-307
        }
}
The effect of proglumide (400 mg/kg), spantide (400 g/kg) and ranitidine (20 mg/kg) on pancreatic secretory and trophic response to bombesin (10 micrograms/kg) was studied in the rat. Drugs were administered alone or combined with bombesin three times daily for 5 days. Saline-treated rats were used as controls. At the end of treatment, animals were anaesthetized and pancreatic juice was collected for 1 h after caerulein stimulation (1 microgram/kg intraperitoneally). Afterwards, rats were… Expand
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