Bombesin-induced HPA and sympathetic activation requires CRH receptors

@article{Kent2001BombesininducedHA,
  title={Bombesin-induced HPA and sympathetic activation requires CRH receptors},
  author={Pam Kent and Tania B{\'e}dard and Samir Khan and Hymie Anisman and Zul Merali},
  journal={Peptides},
  year={2001},
  volume={22},
  pages={57-65}
}
Central administration of bombesin (BN) (into the ventricular system) increased circulating levels of ACTH, corticosterone, epinephrine, norepinephrine and glucose, indicating that this peptide activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system. We then assessed the potential contribution of corticotropin-releasing hormone (CRH) system, in the mediation of these BN effects. Blockade of CRH receptors with alphah-CRF (10 microg) attenuated or blocked the BN… Expand
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