Bombesin-dependent pro-MMP-9 activation in prostatic cancer cells requires beta1 integrin engagement.

@article{Festuccia2002BombesindependentPA,
  title={Bombesin-dependent pro-MMP-9 activation in prostatic cancer cells requires beta1 integrin engagement.},
  author={Claudio Festuccia and Adriano Angelucci and Giovanni Luca Gravina and Enrica Eleuterio and Carlo Vicentini and M. Bologna},
  journal={Experimental cell research},
  year={2002},
  volume={280 1},
  pages={1-11}
}
Bombesin-like peptides, including the mammalian homologue gastrin-releasing peptide, are highly expressed and secreted by neuroendocrine cells in prostate carcinoma tissues and are likely to be related to the progression of this neoplastic disease. Previously, we demonstrated that bombesin increased migration and protease expression in androgen-independent cells. In this work we show that bombesin is able to activate pro-MMP-9 through a mechanism involving the beta1 integrin subunit. In fact… CONTINUE READING

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