Bombesin antagonists inhibit proangiogenic factors in human experimental breast cancers

  title={Bombesin antagonists inhibit proangiogenic factors in human experimental breast cancers},
  author={Ana M Bajo and Andrew V Schally and Kate Groot and Karoly Szepesh{\'a}zi},
  journal={British Journal of Cancer},
  pages={245 - 252}
The overexpression of angiogenic factors such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and insulin-like growth factors (IGFs) plays a role in the migration and proliferation of endothelial cells in many cancers. Consequently, we investigated the effects of bombesin/gastrin-releasing peptide (GRP) antagonists on the expression of these angiogenic factors, the activities of matrix metalloproteinases (MMPs)-2 and -9, as well as the vascular density in MDA-MB-435… CONTINUE READING
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