Bombesin antagonist-based radioligands for translational nuclear imaging of gastrin-releasing peptide receptor-positive tumors.

@article{Abiraj2011BombesinAR,
  title={Bombesin antagonist-based radioligands for translational nuclear imaging of gastrin-releasing peptide receptor-positive tumors.},
  author={Keelara Abiraj and Rosalba Mansi and Maria-Luisa Tamma and M. El Fani and Flavio Forrer and Guillaume P. Nicolas and Renzo Cescato and Jean Claude Reubi and Helmut R. Maecke},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2011},
  volume={52 12},
  pages={1970-8}
}
UNLABELLED Bombesin receptors are overexpressed on a variety of human tumors. In particular, the gastrin-releasing peptide receptor (GRPr) has been identified on prostate and breast cancers and on gastrointestinal stromal tumors. The current study aims at developing clinically translatable bombesin antagonist-based radioligands for SPECT and PET of GRPr-positive tumors. METHODS A potent bombesin antagonist (PEG(4)-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH(2) [AR]) was synthesized; conjugated… CONTINUE READING
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