Corpus ID: 16390193

Bombesin and glucocorticoids stimulate human breast cancer cells to produce endothelin, a paracrine mitogen for breast stromal cells.

@article{Schrey1992BombesinAG,
  title={Bombesin and glucocorticoids stimulate human breast cancer cells to produce endothelin, a paracrine mitogen for breast stromal cells.},
  author={M. Schrey and K. Patel and N. Tezapsidis},
  journal={Cancer research},
  year={1992},
  volume={52 7},
  pages={
          1786-90
        }
}
Human breast cancer cells have been recently reported to produce endothelin (ET) 1. To investigate the potential regulation of ET production in breast cancer cells, we have measured the release of ET-like immunoreactivity from the T47D cell line in response to various paracrine/endocrine factors. Bombesin (0.1 microM) and cortisol (1 microM) stimulated maximal respective increases in IR-ET release to 580 and 369% of basal values after 6 h. The responses to cortisol and bombesin were additive… Expand
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References

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Production of endothelin in human cancer cell lines.
TLDR
Northern blot analysis revealed bands corresponding to ET-1 mRNA in cancer cell lines, indicating that IR-ET-1 produced by cancer cells is a product of the Et-1 gene, raising the possibility that ET- 1 produced bycancer cells plays a modulatory role in the growth of stromal cells surrounding cancer cells. Expand
Activation of inositol phospholipid signaling and Ca2+ efflux in human breast cancer cells by bombesin.
TLDR
Data implicate a functional role for BRPs in human breast cancer by studying their effect on phospholipid hydrolysis, 45Ca2+ efflux, and cell growth in thehuman breast cancer cell line MCF-7 and activation of putative mitogenic signaling pathways. Expand
Modulation of inositol lipid hydrolysis in human breast cancer cells by two classes of bombesin antagonist.
TLDR
Inositol lipid hydrolysis was monitored in the human breast cancer cell line MCF-7 in response to various bombesin (BN) and substance P (SP) analogues to show consistent with the presence of separate but interacting receptors or binding sites for BN and SP analogues, which are coupled to a common signal transduction pathway inhuman breast cancer cells. Expand
Pertussis toxin-sensitive pathway in the stimulation of c-myc expression and DNA synthesis by bombesin.
TLDR
The results suggest that the mitogenic actions of bombesin-like growth factors are mediated through a pertussis toxin-sensitive guanine nucleotide-binding protein and indicate that bombesIn- like growth factors act through pathways that are different from those activated by platelet-derived growth factor. Expand
The biphasic stimulation of insulin secretion by bombesin involves both cytosolic free calcium and protein kinase C.
TLDR
The data indicate that the initial secretory burst induced by bombesin results from the synergistic action of the high [Ca2+]i produced by InsP3 and DAG-activated protein kinase C, which appears to be sufficient for a sustained secretory response. Expand
Cytokine-induced release of endothelin-1 from porcine renal epithelial cell line.
TLDR
Northern blot analysis using cDNA for porcine preproET-1 as a probe revealed a single major band corresponding to the size of ET-1 mRNA in LLCPK1, which indicates that the preproet-1 gene is also expressed in renal epithelial cells and the release of Et-1 from renal cells is regulated by the similar mechanism to that from endothelial cells. Expand
Inducible endothelin mRNA expression and peptide secretion in cultured human vascular smooth muscle cells.
TLDR
It is proposed that VSMC-synthesized ET may function in an autocrine manner to regulate both tone and structural modelling of vasculature to invoke a role for ET which extends beyond the paracrine regulation by peptide synthesized and secreted by endothelial cells. Expand
Inducibleendothelin mRNA expression and peptide secretion in cultured human vascular smooth muscle cells
TLDR
It is proposed that VSMC-synthesized ET may function in an autocrine manner to regulate both tone and structural modelling of vasculature to extend beyond the paracrine regulation by peptide synthesized and secreted by endothelial cells. Expand
Prolactin-inducible proteins in human breast cancer cells.
TLDR
This study examines the effect of human prolactin (hPRL) on the synthesis of unique proteins by a human breast cancer cell line, T-47D, in serum-free medium containing bovine serum albumin, and shows that the hormones' action is at the level of gene expression. Expand
Endothelin stimulates DNA synthesis in Swiss 3T3 cells. Synergy with polypeptide growth factors.
TLDR
Although endothelin has little effect on DNA synthesis when added alone to cells in serum-free medium, the peptide synergizes very strongly with several other growth factors and may prove to be a useful additional agonist for studying the signalling pathways involved in the control of 3T3-cell proliferation. Expand
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