Bombesin and epidermal growth factor stimulate the mitogen-activated protein kinase through different pathways in Swiss 3T3 cells.

@article{Pang1993BombesinAE,
  title={Bombesin and epidermal growth factor stimulate the mitogen-activated protein kinase through different pathways in Swiss 3T3 cells.},
  author={L. Pang and S. Decker and A. Saltiel},
  journal={The Biochemical journal},
  year={1993},
  volume={289 ( Pt 1)},
  pages={
          283-7
        }
}
Both bombesin and epidermal growth factor (EGF) are potent mitogens in Swiss 3T3 cells that nonetheless have dissimilar receptor structures. To explore possible common intracellular events involved in the stimulation of cellular growth by these two peptides, we have evaluated the regulation of the mitogen-activated protein (MAP) kinase. Exposure of Swiss 3T3 cells to bombesin, EGF or the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) causes the rapid and transient stimulation… Expand
EGF receptor function is required in late G(1) for cell cycle progression induced by bombesin and bradykinin.
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