Bombesin and epidermal growth factor potentiate the effect of cytotoxic LH-RH analog AN-152 in vitro.

@article{Krebs2002BombesinAE,
  title={Bombesin and epidermal growth factor potentiate the effect of cytotoxic LH-RH analog AN-152 in vitro.},
  author={L. Krebs and Xiaopeng Wang and A. Nagy and A. Schally and P. Prasad and C. Liebow},
  journal={International journal of oncology},
  year={2002},
  volume={21 6},
  pages={
          1325-9
        }
}
The conjugation of doxorubicin with [D-Lys6] Luteinizing Hormone-Releasing Hormone (LH-RH), yields AN-152, a cytotoxic analog that can be targeted to tumor cells expressing LH-RH receptors. This conjugate is more potent against LH-RH receptor positive cancer cells and has less peripheral toxicity than free doxorubicin. The proliferation of MCF-7 human breast cancer cells in vitro is inhibited by AN-152 and this effect can be augmented by the up-regulation of LH-RH receptor expression through… Expand
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