Bombesin activates large-conductance chloride channels in Swiss 3T3 fibroblasts.

@article{Kawahara1991BombesinAL,
  title={Bombesin activates large-conductance chloride channels in Swiss 3T3 fibroblasts.},
  author={Katsunobu Kawahara and Noriko Takuwa},
  journal={Biochemical and biophysical research communications},
  year={1991},
  volume={177 1},
  pages={292-8}
}
Using the patch-clamp technique (cell-attached patches), we found that bombesin, a Ca-mobilizing peptide mitogen, activates large-conductance Cl channels in Swiss 3T3 fibroblasts. The channel activation required a lag period of about 50 s and was equally observed whether bombesin was applied to the patch-pipette or to the bath. A23187 (10(-6)M) in the bath… CONTINUE READING