Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate.

@article{Zachary1992BombesinVA,
  title={Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate.},
  author={I. Zachary and J. Sinnett-Smith and E. Rozengurt},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 27},
  pages={
          19031-4
        }
}
Neuropeptide-stimulated tyrosine phosphorylation of specific components in Swiss 3T3 cells was investigated using monoclonal antibodies directed against the src transformation-associated substrates p125 focal adhesion kinase (FAK), a novel type of cytosolic tyrosine kinase, and p130. Treatment of Swiss 3T3 cells with the mitogenic peptides bombesin, vasopressin, and endothelin caused a striking increase in the tyrosine phosphorylation of p125FAK, as judged either by anti-phosphotyrosine (anti… Expand
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Two distinct signal transduction pathways that lead to tyrosine phosphorylation of p130(cas) in the same cells are identified and it is suggested that p130 (cas) could play a role in mitogen-mediated signalTransduction. Expand
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