Bolus infusion of human urinary trypsin inhibitor improves intractable interstitial pneumonia in patients with connective tissue diseases.

@article{Tsujimura2008BolusIO,
  title={Bolus infusion of human urinary trypsin inhibitor improves intractable interstitial pneumonia in patients with connective tissue diseases.},
  author={Shizuyo Tsujimura and Kazuyoshi Saito and Shingo Nakayamada and Yoshinori Tanaka},
  journal={Rheumatology},
  year={2008},
  volume={47 6},
  pages={
          907-13
        }
}
OBJECTIVE Interstitial pneumonia (IP) associated with CTDs often progresses despite conventional immunosuppressive treatment. We investigated the efficacy of human urinary trypsin (UT) inhibitor (ulinastatin) on refractory IP. METHODS Five patients with IP received UT inhibitor (3 x 10(5) U) infusion into the internal jugular vein, three times in a single day. The response to this therapy was assessed clinically and by chest CT, PaO(2) and serum KL-6. The kinetics of UT inhibitor was… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 39 references

amplification in patients with connective tissue diseases: re-evaluation of clinical features of P. carinii pneumonia in rheumatic diseases

  • K Hamada, S Nagai, M Kitaichi
  • Rheumatology
  • 2004