Bolus administration of cladribine in the treatment of Waldenström macroglobulinaemia.

  title={Bolus administration of cladribine in the treatment of Waldenstr{\"o}m macroglobulinaemia.},
  author={Elvis S. Liu and Carol Burian and William E. Miller and Alan Saven},
  journal={British journal of haematology},
  volume={103 3},
This phase II clinical trial evaluated bolus cladribine as a single agent in Waldenstrom macroglobulinaemia (WM). Cladribine was administered to 20 patients at a dose of 0.12 mg/kg/d by 2 h intravenous infusion for 5 consecutive days at monthly intervals for three courses. Partially responding patients were continued on therapy until maximal response and/or prohibitive toxicity, to a maximum of eight courses. Complete responders were treated with one additional course of cladribine. After a… CONTINUE READING
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