Body window-enabled in vivo multicolor imaging of transplanted mouse islets expressing an insulin-Timer fusion protein.

@article{Bertera2003BodyWI,
  title={Body window-enabled in vivo multicolor imaging of transplanted mouse islets expressing an insulin-Timer fusion protein.},
  author={Suzanne Bertera and Xuehui Geng and Zakaria S. Tawadrous and Rita Bottino and Appakalai N. Balamurugan and William A. Rudert and Peter F Drain and Simon C Watkins and Massimo Trucco},
  journal={BioTechniques},
  year={2003},
  volume={35 4},
  pages={
          718-22
        }
}
Type 1 diabetes results from the selective destruction of insulin-producing beta cells in the islets of Langerhans, and autoimmune T cells are thought to be the mediators of this destruction. T cells are also responsible for allorejection once the islets are transplanted into a patient to reduce the negative consequences of a lack of insulin. To better understand these processes, we have developed a transgenic mouse expressing proinsulin II tagged with a live-cell fluorescent reporter protein… CONTINUE READING

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  • 2018

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  • 2018
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CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 17 REFERENCES

Gene transfer of manganese superoxide dismutase prolongs transplanted islet function in an autoimmune mouse model of

S. Bertera, M. Crawford, +4 authors M. Trucco
  • diabetes
  • 2003

In - sulin staining of ES cell progeny from insulin uptake

V. M. Subbotin, S. Bertera, A. Alexander, A. J. Styche, M. Trucco
  • Science
  • 2002

Imag - ing secretory vesicles by fluorescent protein insertion in propeptide rather than mature secreted peptide

X. Geng, L. Li, G. Papworth, P. D. Robbins
  • Traffic
  • 2001

"Fluorescent timer": protein that changes color with time.

Alexey Terskikh, Arkady F. Fradkov, +9 authors Paul D. Siebert
  • Science
  • 2000