Body weight is modulated by levels of full-length huntingtin.

@article{Raamsdonk2006BodyWI,
  title={Body weight is modulated by levels of full-length huntingtin.},
  author={Jeremy M Van Raamsdonk and William Thomas Gibson and Jacqueline Pearson and Zoe Murphy and Ge Lu and Blair R. Leavitt and Michael R. Hayden},
  journal={Human molecular genetics},
  year={2006},
  volume={15 9},
  pages={
          1513-23
        }
}
Huntington disease is an adult-onset neurodegenerative disorder that is caused by the expansion of a polyglutamine tract within the Huntingtin (htt) protein. Wild-type htt has been shown to be involved in transcription, transport and cell survival. Here, we demonstrate that increased expression of full-length wild-type htt in mice is associated with a dose-dependent increase in body weight which results from an increase in both total fat mass and fat-free mass. Conversely, we show that a… CONTINUE READING

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Wild-type huntingtin protects against excitotoxicity

  • BR Leavitt, JM VanRaamsdonk, +5 authors MR Hayden
  • J Neurochem
  • 2006
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