Body-wall muscle formation in Caenorhabditis elegans embryos that lack the MyoD homolog hlh-1.

@article{Chen1992BodywallMF,
  title={Body-wall muscle formation in Caenorhabditis elegans embryos that lack the MyoD homolog hlh-1.},
  author={Lihsia Chen and Michael Krause and Bruce W Draper and Harold Weintraub and Andrew Fire},
  journal={Science},
  year={1992},
  volume={256 5054},
  pages={240-3}
}
The myoD family of DNA binding proteins has been implicated in the control of myogenesis in a variety of organisms. Searches for homologs in the nematode Caenorhabditis elegans yielded only one gene, designated hlh-1, expressed in body-wall muscle cells and their precursors. To assess the role of hlh-1 in C. elegans myogenesis, genetic deficiencies spanning the hlh-1 locus were isolated after gamma irradiation. Embryos homozygous for these deficiencies exhibited extensive body-wall muscle… CONTINUE READING
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