Body size and risk of prostate cancer in the European prospective investigation into cancer and nutrition.

Abstract

BACKGROUND Body size has been hypothesized to influence the risk of prostate cancer; however, most epidemiologic studies have relied on body mass index (BMI) to assess adiposity, whereas only a few studies have examined whether body fat distribution predicts prostate cancer. METHODS We examined the association of height, BMI, waist and hip circumference, and waist-hip ratio with prostate cancer risk among 129,502 men without cancer at baseline from 8 countries of the European Prospective Investigation into Cancer and Nutrition (EPIC), using Cox regression, with age as time metric, stratifying by study center and age at recruitment, and adjusting for education, smoking status, alcohol consumption, and physical activity. RESULTS During a mean follow-up of 8.5 years, 2,446 men developed prostate cancer. Waist circumference and waist-hip ratio were positively associated with risk of advanced disease. The relative risk of advanced prostate cancer was 1.06 (95% confidence interval, 1.01-1.1) per 5-cm-higher waist circumference and 1.21 (95% confidence interval, 1.04-1.39) per 0.1-unit-higher waist-hip ratio. When stratified by BMI, waist circumference and waist-hip ratio were positively related to risk of total, advanced, and high-grade prostate cancer among men with lower but not among those with higher BMI (Pinteraction for waist with BMI, 0.25, 0.02, and 0.05, respectively; Pinteraction for waist-hip ratio with BMI, 0.27, 0.22, and 0.14; respectively). CONCLUSIONS These data suggest that abdominal adiposity may be associated with an increased risk of advanced prostate cancer. This association may be stronger among individuals with lower BMI; however, this finding needs confirmation in future studies.

DOI: 10.1158/1055-9965.EPI-08-0609

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@article{Pischon2008BodySA, title={Body size and risk of prostate cancer in the European prospective investigation into cancer and nutrition.}, author={Tobias Pischon and H. Boeing and Steffen Weikert and Naomi E. Allen and Timothy J Key and Nina F\ons Johnsen and Anne Marie Tj\onneland and Marianne Tang Severinsen and Kim Overvad and Sabine Rohrmann and Rudolf Kaaks and Antonia Trichopoulou and Gitaki Zoi and Dimitirios Trichopoulos and Valeria Pala and Domenico Palli and Rosario Tumino and Carlotta Sacerdote and Hendrik Bas Bueno-de-Mesquita and Anne M May and Jonas Manjer and Peter Wallstr{\"{o}m and P{\"a}r Stattin and G{\"{o}ran Hallmans and Genevieve G Buckland and Nerea Larra{\~n}aga Larra{\~n}aga and M D Chirlaque and Carmen Mart{\'i}nez and Maria Luisa Redondo Cornejo and Eva Ardanaz and Sheila Anne Bingham and Kay-Tee Khaw and Sabina Rinaldi and Nadia Slimani and M. Jenab and Elio Riboli}, journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology}, year={2008}, volume={17 11}, pages={3252-61} }