Body size, IGF and growth hormone polymorphisms, and colorectal adenomas and hyperplastic polyps.

@article{Wernli2010BodySI,
  title={Body size, IGF and growth hormone polymorphisms, and colorectal adenomas and hyperplastic polyps.},
  author={Karen Wernli and Polly A Newcomb and Yinghui Wang and Karen W. Makar and Mazyar Shadman and Victoria M. Chia and Andrea N. Burnett-Hartman and Michelle A. Wurscher and Yingye Zheng and Margaret T. Mandelson},
  journal={Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society},
  year={2010},
  volume={20 4},
  pages={305-9}
}
OBJECTIVE We examined the risk of colorectal polyps in relation to body size factors and candidate polymorphisms in selected genes of insulin-like growth factor (IGF1) (rs5742612), IGF1 receptor (IGF1R) (rs2229765), IGF binding protein 3 (IGFBP3) (rs2854746) and growth hormone (GH1) (rs2665802). DESIGN Cases with colorectal adenomas (n=519), hyperplastic polyps (n=691), or both lesions (n=227), and controls (n=772), aged 20-74 years, were recruited from patients who underwent colonoscopy… CONTINUE READING

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