Body mass index, physical activity, and colorectal cancer by anatomical subsites: a systematic review and meta-analysis of cohort studies

@article{Robsahm2013BodyMI,
  title={Body mass index, physical activity, and colorectal cancer by anatomical subsites: a systematic review and meta-analysis of cohort studies},
  author={Trude Eid Robsahm and Bjarte Aagnes and Anette Hjart{\aa}ker and Hilde Langseth and Freddie Bray and Inger Kristin Larsen},
  journal={European Journal of Cancer Prevention},
  year={2013},
  volume={22},
  pages={492–505}
}
Several studies report varying incidence rates of cancer in subsites of the colorectum, as an increasing proportion appears to develop in the proximal colon. Varying incidence trends together with biological differences between the colorectal segments raise questions of whether lifestyle factors impact on the risk of cancer differently at colorectal subsites. We provide an updated overview of the risk of cancer at different colorectal subsites (proximal colon, distal colon, and rectum… 
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References

SHOWING 1-10 OF 80 REFERENCES
Physical Activity and Risk of Colon and Rectal Cancers: The European Prospective Investigation into Cancer and Nutrition
TLDR
It is found that physical activity reduced colon cancer risk, specifically for right-sided tumors and for lean participants, but not rectal cancer.
Physical activity and risk of colorectal cancer in Japanese men and women: the Japan Public Health Center-based prospective Study
TLDR
It is suggested that physical activity may prevent colorectal cancer among Japanese men, and this inverse association was essentially limited to colon cancer.
Physical activity and risks of proximal and distal colon cancers: a systematic review and meta-analysis.
TLDR
It is suggested that physical activity is associated with a reduced risk of both proximal colon and distal colon cancers, and that the magnitude of the association does not differ by subsite.
Recreational Physical Activity and Cancer Risk in Subsites of the Colon (the Nord-Trøndelag Health Study)
TLDR
The inverse association of recreational physical activity with cancer risk and mortality in the transverse and sigmoid segments of the colon may point at increased colon motility and reduced fecal transit time as possible underlying mechanisms.
A Prospective Study of Body Mass Index, Weight Change, and Risk of Cancer in the Proximal and Distal Colon
TLDR
The results support gender differences and the hypothesis of different etiologies for colon subsites for colon cancer and whether weight loss in the overweight decreases risk of colon cancer warrants further study.
A systematic review of the association between physical activity and colorectal cancer risk
TLDR
Heterogeneity in the evidence from all studies and from the highest quality studies was evident, and evidence from cohort studies is not sufficient to claim a convincing relationship exists between PA and CRC risk.
Body size and composition and colon cancer risk in women
TLDR
Central adiposity appears to be associated with colon cancer risk in women, and there was some evidence that the associations were stronger for proximal tumors, but no evidence that risk differed by stage for any of the anthropometric measures.
Body size and composition and risk of rectal cancer (Australia)
TLDR
Waist circumference and fat mass may be weakly related to risk of rectal cancer and there was no evidence that risk differed by sex for any of the anthropometric measures.
Physical activity, obesity, and risk of colon and rectal cancer in a cohort of Swedish men.
Comparison of risk factors for colon and rectal cancer
TLDR
The findings support previous suggestions that family history and physical activity are not strong contributors to the etiology of rectal cancer and should take into consideration risk factor differences by subsite.
...
...