Body mass index, physical activity, and colorectal cancer by anatomical subsites: a systematic review and meta-analysis of cohort studies

  title={Body mass index, physical activity, and colorectal cancer by anatomical subsites: a systematic review and meta-analysis of cohort studies},
  author={Trude Eid Robsahm and Bjarte Aagnes and Anette Hjart{\aa}ker and Hilde Langseth and Freddie Bray and Inger Kristin Larsen},
  journal={European Journal of Cancer Prevention},
Several studies report varying incidence rates of cancer in subsites of the colorectum, as an increasing proportion appears to develop in the proximal colon. Varying incidence trends together with biological differences between the colorectal segments raise questions of whether lifestyle factors impact on the risk of cancer differently at colorectal subsites. We provide an updated overview of the risk of cancer at different colorectal subsites (proximal colon, distal colon, and rectum… 
Effects of physical activity on colorectal cancer risk among family history and body mass index subgroups: a systematic review and meta-analysis
Overall, a stronger relative risk of physical activity on colorectal cancer risk was observed in the higher body mass index group, although the difference was not statistically significant, suggesting an added benefit ofPhysical activity as a cancer prevention strategy in population groups with strong risk factors for coloreCTal cancer.
Physical activity and mortality in patients with colorectal cancer: a meta-analysis of prospective cohort studies.
A systematic review and meta-analysis provides comprehensive evidence that PA performed before or after cancer diagnosis is related to reduced mortality risk among CRC survivors.
Physical Activity and Colorectal Cancer Risk by Sex, Race/Ethnicity, and Subsite: The Multiethnic Cohort Study
The findings confirm the inverse association between physical activity and colorectal cancer, which appears to be stronger in men, and suggest possible differences in the strength of the association by race/ethnicity and anatomic subsite of tumors.
Association of physical activity and sitting time with incident colorectal cancer in postmenopausal women
An inverse association between leisure time PA and the risk of CRC, particularly for rectal cancer is observed, and there was no association between ST and CRC in multivariable models.
The importance of physical activity in colorectal cancer prevention
  • N. Antoljak
  • Medicine
    Libri Oncologici Croatian Journal of Oncology
  • 2020
In most observational studies, greater physical activity is associated with a lower incidence of colon cancer, while in the interventional studies, results were more diverse.
Height and body fatness and colorectal cancer risk: an update of the WCRF–AICR systematic review of published prospective studies
The positive association between height and risk of CRC suggests that life factors during childhood and early adulthood might play a role in CRC aetiology.
Physical activity, obesity and sedentary behaviour and the risks of colon and rectal cancers in the 45 and up study
Evidence suggests that a healthy weight and vigorous activity are essential to reduce CC risk since these factors may be independent of each other.
Domain-specific physical activity and sedentary behaviour in relation to colon and rectal cancer risk: a systematic review and meta-analysis.
In addition to increasing occupational and recreational physical activity, promoting physical activity during transport and reducing sedentary behaviour in the workplace may also be useful colorectal cancer prevention strategies.
Association of sedentary work with colon and rectal cancer: systematic review and meta-analysis
Evidence is found of association between sedentary work and the risk of colon or rectal cancer, independent of sex, control of body mass index and assessment of sedentary behaviour, which could be an important means of preventing colon andrectal cancer.
Physical Activity and Gastric Cancer Risk: A Systematic Review and Meta-Analysis
This meta-analysis suggests a protective effect of physical activity regarding gastric cancer risk, especially in Asian populations.


Physical Activity and Risk of Colon and Rectal Cancers: The European Prospective Investigation into Cancer and Nutrition
It is found that physical activity reduced colon cancer risk, specifically for right-sided tumors and for lean participants, but not rectal cancer.
Physical activity and risk of colorectal cancer in Japanese men and women: the Japan Public Health Center-based prospective Study
It is suggested that physical activity may prevent colorectal cancer among Japanese men, and this inverse association was essentially limited to colon cancer.
Physical activity and risks of proximal and distal colon cancers: a systematic review and meta-analysis.
It is suggested that physical activity is associated with a reduced risk of both proximal colon and distal colon cancers, and that the magnitude of the association does not differ by subsite.
Recreational Physical Activity and Cancer Risk in Subsites of the Colon (the Nord-Trøndelag Health Study)
The inverse association of recreational physical activity with cancer risk and mortality in the transverse and sigmoid segments of the colon may point at increased colon motility and reduced fecal transit time as possible underlying mechanisms.
A Prospective Study of Body Mass Index, Weight Change, and Risk of Cancer in the Proximal and Distal Colon
The results support gender differences and the hypothesis of different etiologies for colon subsites for colon cancer and whether weight loss in the overweight decreases risk of colon cancer warrants further study.
A systematic review of the association between physical activity and colorectal cancer risk
Heterogeneity in the evidence from all studies and from the highest quality studies was evident, and evidence from cohort studies is not sufficient to claim a convincing relationship exists between PA and CRC risk.
Body size and composition and colon cancer risk in women
Central adiposity appears to be associated with colon cancer risk in women, and there was some evidence that the associations were stronger for proximal tumors, but no evidence that risk differed by stage for any of the anthropometric measures.
Body size and composition and risk of rectal cancer (Australia)
Waist circumference and fat mass may be weakly related to risk of rectal cancer and there was no evidence that risk differed by sex for any of the anthropometric measures.
Physical activity, obesity, and risk of colon and rectal cancer in a cohort of Swedish men.
Comparison of risk factors for colon and rectal cancer
The findings support previous suggestions that family history and physical activity are not strong contributors to the etiology of rectal cancer and should take into consideration risk factor differences by subsite.