Body fluid proteomics: Prospects for biomarker discovery.

  title={Body fluid proteomics: Prospects for biomarker discovery.},
  author={Sung-Min Ahn and Richard J. Simpson},
  journal={Proteomics. Clinical applications},
  volume={1 9},
Many diseases are caused by perturbations of cellular signaling pathways and related pathway networks as a result of genetic aberrations. These perturbations are manifested by altered cellular protein profiles in the fluids bathing tissue/organs (i.e., the tissue interstitial fluid, TIF). A major challenge of clinical chemistry is to quantitatively map these perturbed protein profiles - the so-called "signatures of disease" - using modern proteomic technologies. This information can be utilized… CONTINUE READING


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