Body composition and quality of life in adults with growth hormone deficiency; effects of low‐dose growth hormone replacement

@article{Ahmad2001BodyCA,
  title={Body composition and quality of life in adults with growth hormone deficiency; effects of low‐dose growth hormone replacement},
  author={A. M. R. Ahmad and Marion T. Hopkins and J Thom{\'a}s and Hisham Saleh Ibrahim and William D. Fraser and Jiten P. Vora},
  journal={Clinical Endocrinology},
  year={2001},
  volume={54}
}
OBJECTIVE Adult growth hormone deficiency (AGHD) is characterized by abnormalities in body composition and a poor perceived quality of life (QoL). Weight‐based high‐dose growth hormone replacement (GHR) results in improvements in body composition and QoL in AGHD. However, a high patient percentage reported side‐effects on high‐dose GHR resulting in a high rate of patient withdrawal from growth hormone (GH) treatment. High‐dose GH therapy also leads to supraphysiological serum insulin‐like… Expand
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Citation Type

Adult Growth Hormone Deficiency – Benefits, Side Effects, and Risks of Growth Hormone Replacement
TLDR
When dosed appropriately, GH replacement therapy (GHRT) is well tolerated, with a low incidence of side effects, and improves most of the alterations observed in GH deficiency (GHD); beneficial effects on mortality, cardiovascular events, and fracture rates remain to be conclusively demonstrated. Expand
The influence of growth hormone status on physical impairments, functional limitations, and health-related quality of life in adults.
TLDR
Review of placebo-controlled trials to date suggests that GH and somatostatin analogs have greater effects on gas exchange and aerobic performance than as anabolic agents on skeletal muscle mass and function. Expand
Growth Hormone Therapy and Quality of Life in Adults and Children
TLDR
Translating changes in QOL, together with physiological and metabolic benefits, into economic cost-benefit or cost-effectiveness analyses are needed, and it will be important to consider subgroups of patients who may derive differential benefit from GH treatment. Expand
Impact of Long-Term Growth Hormone Replacement Therapy on Metabolic and Cardiovascular Parameters in Adult Growth Hormone Deficiency: Comparison Between Adult and Elderly Patients
TLDR
The increases in glucose levels, BMI, and SBP in GHD negatively affected the prevalence of Metabolic Syndrome in the long term, especially in AGHD patients, and the effects on body composition and lipid profile are prominent. Expand
Quality of Life in Adult Growth Hormone Deficiency
TLDR
GHD long-term survivors of childhood cancer seem to benefit from GH replacement to a similar extent as hypopituitary patients, whereas the benefit to elderly GHD adults remains unclear. Expand
Adult growth hormone replacement: current understanding.
  • R. Murray
  • Biology, Medicine
  • Current opinion in pharmacology
  • 2003
TLDR
Weight-based dosing regimens resulted in lower overall doses in females who require approximately threefold greater GH secretion in health to maintain a similar insulin-like growth factor-I level to males, which explains studies reporting that males respond more efficaciously to GH replacement. Expand
Use of growth hormone for prevention or treatment of effects of aging.
  • S. M. Harman, M. Blackman
  • Medicine
  • The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2004
TLDR
Treatment of elderly individuals with rhGH should be confined to controlled research studies, and clinically significant functional benefits, prolongation of youth, and life extension have not been demonstrated. Expand
Long-Term Growth Hormone Replacement Therapy in Hypopituitary Adults
TLDR
It appears not only that long-term GH replacement therapy in adults with GHD is a procedure that can be safely used, but that GH replacement should be considered as a possible life-long therapy in order to maintain its benefits. Expand
Growth hormone therapy and Quality of Life: possibilities, pitfalls and mechanisms.
TLDR
This paper analyses studies investigating the relationship between GH and QoL in GH-deficient children or adults, inGH-replete short children suffering from idiopathic short stature, Turner syndrome, or intrauterine growth retardation and in GH -deficient or replete elderly adults. Expand
Growth Hormone Replacement Therapy in Adults: Responsiveness Related to Life Quality
TLDR
There is a growing body of evidence for an impairment of QoL in GH-deficient patients and an improvement or normalization after GH replacement exists, and the therapeutic mechanisms of GH replacement are discussed. Expand
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