Body composition and quality of life in adults with growth hormone deficiency; effects of low‐dose growth hormone replacement

@article{Ahmad2001BodyCA,
  title={Body composition and quality of life in adults with growth hormone deficiency; effects of low‐dose growth hormone replacement},
  author={A. M. R. Ahmad and Marion T. Hopkins and J Thom{\'a}s and Hisham Saleh Ibrahim and William D. Fraser and Jiten P. Vora},
  journal={Clinical Endocrinology},
  year={2001},
  volume={54}
}
OBJECTIVE Adult growth hormone deficiency (AGHD) is characterized by abnormalities in body composition and a poor perceived quality of life (QoL). Weight‐based high‐dose growth hormone replacement (GHR) results in improvements in body composition and QoL in AGHD. However, a high patient percentage reported side‐effects on high‐dose GHR resulting in a high rate of patient withdrawal from growth hormone (GH) treatment. High‐dose GH therapy also leads to supraphysiological serum insulin‐like… 
View on Wiley
ncbi.nlm.nih.gov
71 Citations
Highly Influential Citations
3
Background Citations
14
Methods Citations
5
Results Citations
3

71 Citations

Adult Growth Hormone Deficiency – Benefits, Side Effects, and Risks of Growth Hormone Replacement

When dosed appropriately, GH replacement therapy (GHRT) is well tolerated, with a low incidence of side effects, and improves most of the alterations observed in GH deficiency (GHD); beneficial effects on mortality, cardiovascular events, and fracture rates remain to be conclusively demonstrated.

The influence of growth hormone status on physical impairments, functional limitations, and health-related quality of life in adults.

Review of placebo-controlled trials to date suggests that GH and somatostatin analogs have greater effects on gas exchange and aerobic performance than as anabolic agents on skeletal muscle mass and function.

Growth Hormone Therapy and Quality of Life in Adults and Children

Translating changes in QOL, together with physiological and metabolic benefits, into economic cost-benefit or cost-effectiveness analyses are needed, and it will be important to consider subgroups of patients who may derive differential benefit from GH treatment.

Impact of Long-Term Growth Hormone Replacement Therapy on Metabolic and Cardiovascular Parameters in Adult Growth Hormone Deficiency: Comparison Between Adult and Elderly Patients

The increases in glucose levels, BMI, and SBP in GHD negatively affected the prevalence of Metabolic Syndrome in the long term, especially in AGHD patients, and the effects on body composition and lipid profile are prominent.

Quality of Life in Adult Growth Hormone Deficiency

Adult growth hormone replacement: current understanding.

  • R. Murray
  • Medicine, Biology
    Current opinion in pharmacology
  • 2003

Use of growth hormone for prevention or treatment of effects of aging.

  • S. HarmanM. Blackman
  • Medicine, Biology
    The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2004
Treatment of elderly individuals with rhGH should be confined to controlled research studies, and clinically significant functional benefits, prolongation of youth, and life extension have not been demonstrated.

Long-Term Growth Hormone Replacement Therapy in Hypopituitary Adults

It appears not only that long-term GH replacement therapy in adults with GHD is a procedure that can be safely used, but that GH replacement should be considered as a possible life-long therapy in order to maintain its benefits.

Growth hormone therapy and Quality of Life: possibilities, pitfalls and mechanisms.

This paper analyses studies investigating the relationship between GH and QoL in GH-deficient children or adults, inGH-replete short children suffering from idiopathic short stature, Turner syndrome, or intrauterine growth retardation and in GH -deficient or replete elderly adults.

Growth Hormone Replacement Therapy in Adults: Responsiveness Related to Life Quality

...

References

SHOWING 1-10 OF 41 REFERENCES

The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency.

It is concluded that growth hormone has a role in the regulation of body composition in adults, probably through its anabolic and lipolytic actions.

Treatment of adults with growth hormone (GH) deficiency with recombinant human GH.

The results show that GH replacement in GHD adults results in marked alterations in body composition, fat distribution, and bone and mineral metabolism and reduces psychiatric symptoms.

Growth hormone treatment in growth hormone-deficient adults. I. Effects on muscle mass and strength.

It is concluded that rhGH increases lean tissue and skeletal muscle mass in adults with human GH deficiency, this suggests a role for GH in the regulation of body composition of adult humans and the increase in strength of limb girdle muscles after rhGH treatment suggests that adults with GH deficiency may have a proximal myopathy.

Body composition, bone metabolism, and heart structure and function in growth hormone (GH)-deficient adults before and after GH replacement therapy at low doses.

The results suggest that prolonged GH deficiency induces alterations in body composition and bone metabolism and density, and impairment of cardiac structure and function in adult life.

Quality of life in adults with growth hormone (GH) deficiency: response to treatment with recombinant human GH in a placebo-controlled 21-month trial.

The data demonstrate that GH, which is known to have multiple somatic effects, produces an improvement in the quality of life of adults with GHD.

Effects of growth hormone replacement on physical performance and body composition in GH deficient adults

The aims of this study were to determine the effects of GH replacement on physical performance and body composition in GH deficient (GHD) adults.

The Australian Multicenter Trial of Growth Hormone (GH) Treatment in GH-Deficient Adults.

GH treatment in adults with GH deficiency resulted in prominent increases in serum IGF-I at the doses employed, in some cases to supraphysiological levels, together with substantial reductions in total-body and truncal fat mass consistent with an improved cardiovascular risk profile and modest improvements in perceived quality of life.

Metabolic actions of growth hormone in man.

There is strong evidence that GH continues to exert significant biological effects on body metabolism in adult humans and the finding of increased adiposity in GH deficiency (GHD) and reduced fat mass in acromegaly.

The growth hormone deficiency syndrome in adults

The aims of this review are to summarize the recent studies of GH treatment in adults with GH deficiency, thereby defining the syndrome of GH deficiency in adults, and to highlight areas for future investigation.

Body composition in growth hormone-deficient adults.

Body composition in a group of growth hormone (GH)-deficient adults was compared with a control group matched for age, sex, body height, body weight, and body mass index by using bioelectrical…