Body composition and adipose tissue cellularity before and after jejuno‐ileostomy in severely obese subjects

  title={Body composition and adipose tissue cellularity before and after jejuno‐ileostomy in severely obese subjects},
  author={Jason G. Kral and Per Bj{\"o}rntorp and Tore Scherst{\'e}n and Lars Sj{\"o}str{\"o}m},
  journal={European Journal of Clinical Investigation},
Abstract. In severe obesity with adipose tissue hyperplasia it is difficult to achieve and sustain weight decrease by conventional therapy. Fifteen severely obese patients (mean body weight 135 kg) with hyperplastic obesity had a jejuno‐ileostomy according to Payne to induce weight reduction by controlled malabsorption. Body composition, adipose tissue cellularity, and glucose tolerance were studied before and after the operation when the patients had reached a new stable weight (WS) a mean 21… 

Effects of jejuno‐ileal bypass on serum lipoproteins and glucose tolerance in severely obese patients

There were statistically significant reductions in blood glucose and plasma insulin as well as serum total cholesterol and lipoprotein fractions and the low preoperative HDL levels decreased.

Surgical treatment of regional adiposity. Lipectomy versus surgically induced weight loss.

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  • Medicine
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It is concluded that lipectomy is not a treatment for obesity with very rare exceptions, though risk-reducing beneficial metabolic effects are achieved after gastrointestinal obesity surgery.

Regional differences in the lipolytic response of the subcutaneous fat depots to prolonged exercise and severe energy deficiency

Positive correlations were found between the fat cell weights estimated in the gluteal tissue samples and the pre-exercise free fatty acid (FFA) levels and the plasma free glycerol obtained five minutes after the bicycle exercise, which may indicate thatgluteal fat deposits are more important for energy provision than abdominal and, especially, femoral deposits.

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Severe, long-term food deprivation followed by refeeding causes loss and recovery of stromal-vascular cells in adipose tissue but no loss of fat cells.

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The majority of clinical studies in surgery have focused more on substrate flux and energy consumption than on body composition, and it is natural that surgeons have demonstrated the greatest interest in applying body composition studies clinically.

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Obesity is associated with macrophage accumulation in adipose tissue.

Transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob) found that the expression of 1,304 transcripts correlated significantly with body mass.

Regional fat loss from the thigh in obese women after adrenergic modulation.

It is concluded that local fat reduction from the thigh can be safely accomplished, both by injection and by cream.



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    Scandinavian journal of plastic and reconstructive surgery
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Five patients with a mean body weight of 136 kg with hyperplastic obesity who after a mean weight reduction of 46 kg by conventional therapy were subjected to extensive plastic surgery aimed at removing supernumerary fat cells, finding no indications that this reduction of adipose tissue mass could prevent the recurrence of obesity in these patients.

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The long-term prognosis for weight reduction is worse for hypercellular forms of obesity than for the hypertrophic form, however, this does not mean that patients with hyper Cellular Forms of obesity should not be treated at all since their serious spontaneous weight development might be lessened by repeated treatments.

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The results suggest that when the fat cell size in different regions of an individual are known, as well as the total fat cell number, the success of an energy-reduced dietary regimen might be approximately predicted both in terms of remaining total body fat and in regional fat depot decrease.

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It is concluded that the size of the adipocytes rather than the number is important for a presumed lipostatic regulation of adipose tissue mass in the adult male Sprague-Dawley rat.

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Study of adipose cell number revealed that obese adolescents display hypercellularity comparable to that observed in obese adults, and decreased rates of lipolysis of smaller adipocytes were associated with the improved lipid and glucose metabolism found in obese subjects after weight reduction.

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There was no correlation between the rate of weight loss and the change in steatosis or liver function, and within the first postoperative year there was a substantial and significant increase in serum alanine-aminotransferase and a minor increase in alkaline phosphatases and BSP.

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