Bodies of evidence - compartmentalization of the piRNA pathway in mouse fetal prospermatogonia.

@article{Heijden2010BodiesOE,
  title={Bodies of evidence - compartmentalization of the piRNA pathway in mouse fetal prospermatogonia.},
  author={Godfried W. van der Heijden and Julio Casta{\~n}eda and Alex Bortvin},
  journal={Current opinion in cell biology},
  year={2010},
  volume={22 6},
  pages={752-7}
}
Epigenetic reprogramming of embryonic mouse germ cells involves DNA demethylation of the genome that is accompanied by derepression of transposable elements (TEs). Threatening the genome's integrity, TE activation is efficiently countered by the concerted action of de novo DNA methylation and PIWI-interacting small RNAs (piRNAs). Recent studies have closely examined the subcellular localization of various piRNA pathway proteins in fetal prospermatogonia of wild-type and piRNA pathway mutant… CONTINUE READING