Bocavirus Infection Induces a DNA Damage Response That Facilitates Viral DNA Replication and Mediates Cell Death

@article{Luo2010BocavirusII,
  title={Bocavirus Infection Induces a DNA Damage Response That Facilitates Viral DNA Replication and Mediates Cell Death},
  author={Y. Luo and A. Chen and J. Qiu},
  journal={Journal of Virology},
  year={2010},
  volume={85},
  pages={133 - 145}
}
  • Y. Luo, A. Chen, J. Qiu
  • Published 2010
  • Medicine, Biology
  • Journal of Virology
  • ABSTRACT Minute virus of canines (MVC) is an autonomous parvovirus that replicates efficiently without helper viruses in Walter Reed/3873D (WRD) canine cells. We previously showed that MVC infection induces mitochondrion-mediated apoptosis and G2/M-phase arrest in infected WRD cells. However, the mechanism responsible for these effects has not been established. Here, we report that MVC infection triggers a DNA damage response in infected cells, as evident from phosphorylation of H2AX and RPA32… CONTINUE READING
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