Bmp4 mediates apoptotic cell death in the developing chick eye.

@article{Trousse2001Bmp4MA,
  title={Bmp4 mediates apoptotic cell death in the developing chick eye.},
  author={Françoise Trousse and Pilar Albors Esteve and Paola Bovolenta},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 4},
  pages={
          1292-301
        }
}
The bone morphogenetic protein (BMP) expression in vertebrates suggests a reiterative function of these molecules during eye development. However, genetic analysis in mice has provided only partial information. Using the chick embryo as a model system, we have analyzed possible additional functions of BMP4 during optic cup formation. Here we describe the expression pattern of Bmp4 and Bmp7 and we show that, in contrast to the mouse, the prospective lens placode ectoderm expresses high levels of… CONTINUE READING

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