Bmp signaling is required for development of primary lens fiber cells.

@article{Faber2002BmpSI,
  title={Bmp signaling is required for development of primary lens fiber cells.},
  author={Sonya C. Faber and M. L. Robinson and Helen P. Makarenkova and Richard A Lang},
  journal={Development},
  year={2002},
  volume={129 15},
  pages={3727-37}
}
We have investigated the role of Bmp signaling in development of the mouse lens using three experimental strategies. First, we have shown that the Bmp ligand inhibitor noggin can suppress the differentiation of primary lens fiber cells in explant culture. Second, we have expressed a dominant-negative form of the type 1 Bmp family receptor Alk6 (Bmpr1b -- Mouse Genome Informatics) in the lens in transgenic mice and shown that an inhibition of primary fiber cell differentiation can be detected at… CONTINUE READING

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