Bmi1 overexpression in the cerebellar granule cell lineage of mice affects cell proliferation and survival without initiating medulloblastoma formation

@inproceedings{Behesti2013Bmi1OI,
  title={Bmi1 overexpression in the cerebellar granule cell lineage of mice affects cell proliferation and survival without initiating medulloblastoma formation},
  author={Hourinaz Behesti and Heeta Bhagat and Adrian M. Dubuc and Michael D. Taylor and S. Marino},
  booktitle={Disease models & mechanisms},
  year={2013}
}
BMI1 is a potent inducer of neural stem cell self-renewal and neural progenitor cell proliferation during development and in adult tissue homeostasis. It is overexpressed in numerous human cancers - including medulloblastomas, in which its functional role is unclear. We generated transgenic mouse lines with targeted overexpression of Bmi1 in the cerebellar… CONTINUE READING