Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

Abstract

Overexpression of the polycomb group gene Bmi1 promotes cell proliferation and induces leukaemia through repression of Cdkn2a (also known as ink4a/Arf) tumour suppressors. Conversely, loss of Bmi1 leads to haematological defects and severe progressive neurological abnormalities in which de-repression of the ink4a/Arf locus is critically implicated. Here, we… (More)
DOI: 10.1038/nature02385

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