Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

@article{Leung2004Bmi1IE,
  title={Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas},
  author={Carly Leung and Merel Lingbeek and Olga Shakhova and James Liu and Ellen Tanger and Parvin Saremaslani and Maarten van Lohuizen and Silvia Marino},
  journal={Nature},
  year={2004},
  volume={428},
  pages={337-341}
}
Overexpression of the polycomb group gene Bmi1 promotes cell proliferation and induces leukaemia through repression of Cdkn2a (also known as ink4a/Arf) tumour suppressors. Conversely, loss of Bmi1 leads to haematological defects and severe progressive neurological abnormalities in which de-repression of the ink4a/Arf locus is critically implicated. Here, we show that Bmi1 is strongly expressed in proliferating cerebellar precursor cells in mice and humans. Using Bmi1-null mice we demonstrate a… Expand
Bmi1 directly represses p21Waf1/Cip1 in Shh-induced proliferation of cerebellar granule cell progenitors
Bmi1, the main component of the Polycomb repressive complex 1, plays a key role in self-renewal of stem cells as well as in proliferation of progenitor cells and senescence, at least in part throughExpand
Bmi1 overexpression in the cerebellar granule cell lineage of mice affects cell proliferation and survival without initiating medulloblastoma formation
SUMMARY BMI1 is a potent inducer of neural stem cell self-renewal and neural progenitor cell proliferation during development and in adult tissue homeostasis. It is overexpressed in numerous humanExpand
Bmi1 overexpression in the cerebellar granule cell lineage of mice affects cell proliferation and survival without initiating medulloblastoma formation
SUMMARY BMI1 is a potent inducer of neural stem cell self-renewal and neural progenitor cell proliferation during development and in adult tissue homeostasis. It is overexpressed in numerous humanExpand
GFAP-Cre-Mediated Transgenic Activation of Bmi1 Results in Pituitary Tumors
Bmi1 is a member of the polycomb repressive complex 1 and plays different roles during embryonic development, depending on the developmental context. Bmi1 over expression is observed in many types ofExpand
Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells
Bmi1 is a key stem cell regulatory gene implicated in the pathogenesis of many aggressive cancers, including medulloblastoma. Overexpression of Bmi1 promotes cell proliferation and is required forExpand
Bmi1 is required for Hedgehog pathway-driven medulloblastoma expansion.
Inappropriate Hedgehog (Hh) signaling underlies development of a subset of medulloblastomas, and tumors with elevated HH signaling activity express the stem cell self-renewal gene BMI1. To testExpand
p27Kip1, a double-edged sword in Shh-mediated medulloblastoma
Medulloblastoma, a brain tumor arising in the cerebellum, is the most common solid childhood malignancy. The current standard of care for medulloblastoma leaves survivors with life-long side effects.Expand
Differentiation of postnatal cerebellar glial progenitors is controlled by Bmi1 through BMP pathway inhibition
Bmi1 is a polycomb group (Pc‐G) protein involved in heritable gene repression, maintenance of cell identity, and proliferation. During the development of the central nervous system, Bmi1 is crucialExpand
Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma
Summary We describe molecular convergence between BMI1 and CHD7 in the initiation of medulloblastoma. Identified in a functional genomic screen in mouse models, a BMI1High;CHD7Low expressionExpand
Bmi1 Loss Produces an Increase in Astroglial Cells and a Decrease in Neural Stem Cell Population and Proliferation
The polycomb transcriptional repressor Bmi1 promotes cell cycle progression, controls cell senescence, and is implicated in brain development. Loss of Bmi1 leads to a decreased brain size and causesExpand
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