Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

@article{Leung2004Bmi1IE,
  title={Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas},
  author={C. Leung and Merel Lingbeek and O. Shakhova and J. Liu and E. Tanger and P. Saremaslani and M. Lohuizen and S. Marino},
  journal={Nature},
  year={2004},
  volume={428},
  pages={337-341}
}
  • C. Leung, Merel Lingbeek, +5 authors S. Marino
  • Published 2004
  • Biology, Medicine
  • Nature
  • Overexpression of the polycomb group gene Bmi1 promotes cell proliferation and induces leukaemia through repression of Cdkn2a (also known as ink4a/Arf) tumour suppressors. Conversely, loss of Bmi1 leads to haematological defects and severe progressive neurological abnormalities in which de-repression of the ink4a/Arf locus is critically implicated. Here, we show that Bmi1 is strongly expressed in proliferating cerebellar precursor cells in mice and humans. Using Bmi1-null mice we demonstrate a… CONTINUE READING
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