Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bβ and TSLC1 in neuroblastoma

@article{Ochiai2010Bmi1IA,
  title={Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bβ and TSLC1 in neuroblastoma},
  author={Hidemasa Ochiai and Hisanori Takenobu and Aya Nakagawa and Yoshimi Yamaguchi and Mayumi Kimura and Miki Ohira and Yuko Okimoto and Yasuo Fujimura and Haruhiko Koseki and Yohko Kohno and Akira Nakagawara and Takehiko Kamijo},
  journal={Oncogene},
  year={2010},
  volume={29},
  pages={2681-2690}
}
Recent advances in neuroblastoma (NB) research addressed that epigenetic alterations such as hypermethylation of promoter sequences, with consequent silencing of tumor-suppressor genes, can have significant roles in the tumorigenesis of NB. However, the exact role of epigenetic alterations, except for DNA hypermethylation, remains to be elucidated in NB research. In this paper, we clarified the direct binding of MYCN to Bmi1 promoter and upregulation of Bmi1 transcription by MYCN. Mutation… CONTINUE READING

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