Bmi1 combines with oncogenic KRAS to induce malignant transformation of human pancreatic duct cells in vitro

@article{Chen2016Bmi1CW,
  title={Bmi1 combines with oncogenic KRAS to induce malignant transformation of human pancreatic duct cells in vitro},
  author={Shao-jie Chen and Yin-ting Chen and Lin-juan Zeng and Qiu-bo Zhang and Guo-da Lian and Jia-jia Li and Ke-ge Yang and Chu-mei Huang and Ya-Qing Li and Zhong-hua Chu and Kai-hong Huang},
  journal={Tumor Biology},
  year={2016},
  volume={37},
  pages={11299-11309}
}
It is critical to understand the pathogenesis of preinvasive stages of pancreatic duct adenocarcinoma (PDAC) for developing novel potential diagnostic and therapeutic targets. The polycomb group family member B-lymphoma Moloney murine leukemia virus insertion region-1 (Bmi1) is overexpressed and involved in cancer progression in PDAC; however, its role in the multistep malignant transformation of human pancreatic duct cells has not been directly demonstrated. In this study, we stably expressed… CONTINUE READING
1 Citations
53 References
Similar Papers

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 53 references

Mutated kras activates cdk8 to stimulate the epithelial-to-mesenchymal transition in pancreatic cancer in part via the wnt/beta-catenin signaling pathway

  • XuW, Z Wang, ZhangW, K Qian, H Li, D Kong
  • Cancer Lett. 2015;356:613–27
  • 2015
1 Excerpt

Cancer statistics ,

  • M Hidalgo
  • N Engl J Med
  • 2013

Similar Papers

Loading similar papers…