Corpus ID: 201613281

Bmi-1 serves as a potential novel marker for progression in human cutaneous basal cell carcinoma.

@article{Zhu2017Bmi1SA,
  title={Bmi-1 serves as a potential novel marker for progression in human cutaneous basal cell carcinoma.},
  author={Hongyan Zhu and Jian Wu and Xiaomei Cui and Xiaodong Chen},
  journal={International journal of clinical and experimental pathology},
  year={2017},
  volume={10 8},
  pages={
          8928-8935
        }
}
B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) is one of the core members of the PRC1 complex (the polycomb gene family) involved in tumorigenesis. The aim of this study is to investigate the expression and possible function of Bmi-1 in cutaneous basal cell carcinoma (BCC). Here, by immunohistochemical staining, we found that elevated Bmi-1 expression was more commonly observed in fresh BCC tissues compared with normal. Bmi-1 RNAi revealed that suppression of… Expand
Circular RNA hsa_Circ_0005795 mediates cell proliferation of cutaneous basal cell carcinoma via sponging miR-1231
TLDR
Knockdown of Circ_0005795 dramatically reduced cell viability, colony formation, and anti-apoptotic protein levels, while increased caspase-3 activity, and worked as an oncogene in BCC. Expand

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