Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells.

@article{Song2006Bmi1IA,
  title={Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells.},
  author={Libing Song and Mu-sheng Zeng and W Liao and Ling Zhang and Hao-yuan Mo and Wan-Li Liu and J Shao and Qiu-liang Wu and Man-Zhi Li and Yunfei Xia and Liwu Fu and Wen-lin Huang and Goberdhan P Dimri and Vimla Band and Yi-xin Zeng},
  journal={Cancer research},
  year={2006},
  volume={66 12},
  pages={6225-32}
}
The Bmi-1 oncoprotein regulates proliferation and oncogenesis in human cells. Its overexpression leads to senescence bypass in human fibroblasts and immortalization of human mammary epithelial cells. In this study, we report that compared with normal nasopharyngeal epithelial cells (NPEC), Bmi-1 is overexpressed in nasopharyngeal carcinoma cell lines. Importantly, Bmi-1 was also found to be overexpressed in 29 of 75 nasopharyngeal carcinoma tumors (38.7%) by immunohistochemical analysis. In… CONTINUE READING