Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck Squamous Cancer-Derived ALDH1 Positive Cells

@inproceedings{Yu2011Bmi1RS,
  title={Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck 
                        Squamous Cancer-Derived ALDH1 Positive Cells},
  author={Cheng-Chia Yu and Wen-liang Lo and Yi-Wei Chen and Pin-I Huang and H S Hsu and Ling-Ming Tseng and S C Hung and Shou Yen Kao and Charn-Jung Chang and Shih Hwa Chiou},
  booktitle={Journal of oncology},
  year={2011}
}
Recent studies suggest that ALDH1 is a putative marker for HNSCC-derived cancer stem cells. However, the regulation mechanisms that maintain the stemness and metastatic capability of HNSCC-ALDH1(+) cells remain unclear. Initially, HNSCC-ALDH1(+) cells from HNSCC patient showed cancer stemness properties, and high expression of Bmi1 and Snail. Functionally, tumorigenic properties of HNSCC-ALDH1(+) cells could be downregulated by knockdown of Bmi-1. Overexpression of Bmi-1 altered in expression… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 50 extracted citations

Cancer stem cells and tumorigenesis

Biophysics reports • 2018
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 54 references

The Cancer Stem Cell Concept in Progression of Head and Neck Cancer

Journal of oncology • 2009
View 6 Excerpts
Highly Influenced

Dismissing links between HPV and aggressive tongue cancer in young patients.

Annals of oncology : official journal of the European Society for Medical Oncology • 2010

Similar Papers

Loading similar papers…