Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death

@inproceedings{Moran2013BmfUT,
  title={Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death},
  author={Catherine Moran and Amaya Sanz-Rodr{\'i}guez and Alba Jimenez-Pacheco and J Martinez-Villareal and Ross C. McKiernan and Eva M. Jim{\'e}nez-Mateos and Claire M. Mooney and Ina Woods and J H M Prehn and David C. Henshall and Tob{\'i}as Engel},
  booktitle={Cell Death and Disease},
  year={2013}
}
Prolonged seizures (status epilepticus, SE) can cause neuronal death within brain regions such as the hippocampus. This may contribute to impairments in cognitive functioning and trigger or exacerbate epilepsy. Seizure-induced neuronal death is mediated, at least in part, by apoptosis-associated signaling pathways. Indeed, mice lacking certain members of the potently proapoptotic BH3-only subfamily of Bcl-2 proteins are protected against hippocampal damage caused by status epilepticus. The… CONTINUE READING
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