Blunted prolactin responses to d-fenfluramine in sociopathy. Evidence for subsensitivity of central serotonergic function.

@article{OKeane1992BluntedPR,
  title={Blunted prolactin responses to d-fenfluramine in sociopathy. Evidence for subsensitivity of central serotonergic function.},
  author={Veronica O'Keane and Eamonn Moloney and Hugh O'Neill and Annette O'Connor and Coleman Smith and Ted G Dinan},
  journal={The British journal of psychiatry : the journal of mental science},
  year={1992},
  volume={160},
  pages={
          643-6
        }
}
Using a neuroendocrine probe we studied nine male offenders in a forensic hospital, convicted of murder, with a diagnosis of antisocial personality disorder, who had been behaviourally 'quiescent' for varying periods and who had not recently been abusing drugs. Nine healthy age-matched men also participated. All subjects received 30 mg d-fenfluramine (d-FEN), a 5-HT releasing agent, orally, after an overnight fast, and serial samples for prolactin estimation were taken hourly for five hours… CONTINUE READING

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