Blunted oral body temperature response to MK-212 in cocaine addicts.

@article{Lee1994BluntedOB,
  title={Blunted oral body temperature response to MK-212 in cocaine addicts.},
  author={M. A. Lee and Herbert Y. Meltzer},
  journal={Drug and alcohol dependence},
  year={1994},
  volume={35 3},
  pages={
          217-22
        }
}
  • M. Lee, H. Meltzer
  • Published 1 June 1994
  • Psychology, Medicine
  • Drug and alcohol dependence
Previous studies have suggested that chronic cocaine administration may affect serotonergic function and that serotonin (5-HT) may be of importance in cocaine craving. Ten male cocaine addicts and 28 male normal controls were challenged with MK-212 (6-chlor-2-[1-piperazinyl]-pyrazine) (20 mg), a direct acting 5-HT receptor agonist which has affinity for a variety of 5-HT receptor subtypes, and placebo, on separate days. The plasma cortisol and prolactin (PRL) concentrations and oral body… Expand
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