Blunted effects of endothelin upon small subcutaneous resistance arteries of mild essential hypertensive patients.

OBJECTIVE In experimental models of hypertension in the rat, resistance arteries present a blunted response to endothelin, a potent vasoconstrictor peptide. The primary objective of this study was to investigate whether, as in hypertensive rat blood vessels, the response of human resistance arteries to endothelin was altered in essential hypertensive… CONTINUE READING