Blunted angiogenesis and hypertrophy are associated with increased fatigue resistance and unchanged aerobic capacity in old overloaded mouse muscle

@inproceedings{Ballak2016BluntedAA,
  title={Blunted angiogenesis and hypertrophy are associated with increased fatigue resistance and unchanged aerobic capacity in old overloaded mouse muscle},
  author={Sam B. Ballak and Tinelies E Bus{\'e}-Pot and Peter J. Harding and Moi Hoon Yap and Louise Deldicque and Arnold de Haan and Richard T. Jaspers and Hans Degens},
  booktitle={AGE},
  year={2016}
}
We hypothesize that the attenuated hypertrophic response in old mouse muscle is (1) partly due to a reduced capillarization and angiogenesis, which is (2) accompanied by a reduced oxidative capacity and fatigue resistance in old control and overloaded muscles, that (3) can be rescued by the antioxidant resveratrol. To investigate this, the hypertrophic response, capillarization, oxidative capacity, and fatigue resistance of m. plantaris were compared in 9- and 25-month-old non-treated and 25… CONTINUE READING
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