Blue light from light-emitting diodes elicits a dose-dependent suppression of melatonin in humans.

@article{West2011BlueLF,
  title={Blue light from light-emitting diodes elicits a dose-dependent suppression of melatonin in humans.},
  author={Kathleen E. West and Michael R. Jablonski and Benjamin Warfield and Kate S. Cecil and Mary James and Melissa A. Ayers and James Maida and Charles K. Bowen and David H Sliney and Mark D. Rollag and John P. Hanifin and George C. Brainard},
  journal={Journal of applied physiology},
  year={2011},
  volume={110 3},
  pages={
          619-26
        }
}
Light suppresses melatonin in humans, with the strongest response occurring in the short-wavelength portion of the spectrum between 446 and 477 nm that appears blue. Blue monochromatic light has also been shown to be more effective than longer-wavelength light for enhancing alertness. Disturbed circadian rhythms and sleep loss have been described as risk factors for astronauts and NASA ground control workers, as well as civilians. Such disturbances can result in impaired alertness and… Expand
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References

SHOWING 1-10 OF 65 REFERENCES
Differential effects of light wavelength in phase advancing the melatonin rhythm
TLDR
Shorter wavelength light has been shown to be more effective than longer wavelengths in suppressing nocturnal melatonin and phase delaying the melatonin rhythm, strengthening earlier findings that the human circadian system is more sensitive to the short wavelengths of light than the longer wavelengths. Expand
High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light.
TLDR
The findings-that the sensitivity of the human alerting response to light and its thermoregulatory sequelae are blue-shifted relative to the three-cone visual photopic system-indicate an additional role for these novel photoreceptors in modifying human alertness, thermophysiology, and heart rate. Expand
Indirect blue light does not suppress nocturnal salivary melatonin in humans in an automobile setting
TLDR
It is concluded that indirect blue light exposures in automobiles up to 1.25 lx do not cause unintentional chronodisruption via melatonin suppression. Expand
Alerting effects of light are sensitive to very short wavelengths
TLDR
Data suggest that subjective alertness may be maximally sensitive to very short wavelength light, compared to 470 nm light, and alertness levels were significantly higher in 420 nm light and significantly lower in the 600 nm light. Expand
Light emitting diodes can be used to phase delay the melatonin rhythm
TLDR
The data suggest the portable LED light source is an effective way of delivering light to phase shift the melatonin rhythm, with the blue/green LED being the more effective of the two LEDs. Expand
Light-emitting diodes and cool white fluorescent light similarly suppress pineal gland melatonin and maintain retinal function and morphology in the rat.
BACKGROUND AND PURPOSE A novel light-emitting diode (LED) light source for use in animal-habitat lighting was evaluated. METHODS The LED was evaluated by comparing its effectiveness with that ofExpand
Action Spectrum for Melatonin Regulation in Humans: Evidence for a Novel Circadian Photoreceptor
TLDR
The results suggest that, in humans, a single photopigment may be primarily responsible for melatonin suppression, and its peak absorbance appears to be distinct from that of rod and cone cellphotopigments for vision. Expand
Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans.
TLDR
The frequency-specific changes in the waking EEG indicate that short-wavelength light is a powerful agent that immediately attenuates the negative effects of both homeostatic sleep pressure and the circadian drive for sleep on alertness, performance, and the ability to sustain attention. Expand
An action spectrum for melatonin suppression: evidence for a novel non‐rod, non‐cone photoreceptor system in humans
TLDR
The data strongly support a primary role for a novel short‐wavelength photopigment in light‐induced melatonin suppression and provide the first direct evidence of a non‐rod, non‐cone photoreceptive system in humans. Expand
High sensitivity of the human circadian melatonin rhythm to resetting by short wavelength light.
TLDR
It is reported here that the circadian resetting response in humans, as measured by the pineal melatonin rhythm, is also wavelength dependent, and photopic lux, the standard unit of illuminance, is inappropriate when quantifying the photic drive required to reset the human circadian pacemaker. Expand
...
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5
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