Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases.

  title={Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases.},
  author={Christelle de Renty and Nathan A Ellis},
  journal={Ageing research reviews},
Genomic instability is a hallmark of cancer and aging. Premature aging (progeroid) syndromes are often caused by mutations in genes whose function is to ensure genomic integrity. The RecQ family of DNA helicases is highly conserved and plays crucial roles as genome caretakers. In humans, mutations in three RecQ genes - BLM, WRN, and RECQL4 - give rise to Bloom's syndrome (BS), Werner syndrome (WS), and Rothmund-Thomson syndrome (RTS), respectively. WS is a prototypic premature aging disorder… CONTINUE READING
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