Blood vessel maturation in a 3-dimensional spheroidal coculture model: direct contact with smooth muscle cells regulates endothelial cell quiescence and abrogates VEGF responsiveness.

Abstract

Paracrine interactions between endothelial cells (EC) and mural cells act as critical regulators of vessel wall assembly, vessel maturation and define a plasticity window for vascular remodeling. The present study was aimed at studying blood vessel maturation processes in a novel 3-dimensional spheroidal coculture system of EC and smooth muscle cells (SMC… (More)

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@article{Korff2001BloodVM, title={Blood vessel maturation in a 3-dimensional spheroidal coculture model: direct contact with smooth muscle cells regulates endothelial cell quiescence and abrogates VEGF responsiveness.}, author={Thomas Korff and Sarah Kimmina and Georg Martiny-Baron and Hellmut G Augustin}, journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology}, year={2001}, volume={15 2}, pages={447-57} }