Blood urea nitrogen a marker for adverse effects of loop diuretics?

  title={Blood urea nitrogen a marker for adverse effects of loop diuretics?},
  author={Joann Lindenfeld and Robert Schrier},
  journal={Journal of the American College of Cardiology},
  volume={58 4},
Loop diuretics are used in patients with heart failure (HF) to relieve symptoms of systemic and pulmonary venous congestion. Despite their nearly universal use for this indication, loop diuretics have not been shown to improve survival—indeed, a number of recent studies suggest an adverse relationship between the use of loop diuretics and survival (1–3). This is plausible because loop diuretics block sodium chloride absorption at the macula densa in the thick ascending limb of the loop of Henle… CONTINUE READING


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